Non-small-cell lung cancer: how to manage MET exon 14 skipping mutant disease

Juan Bautista Blaquier, Gonzalo Recondo

Abstract

Several oncogenic mechanisms have been identified for MET, including MET amplification, fusions, mutations in the tyrosine kinase domain and exon 14 skipping alterations. MET exon 14 mutations are found in about 3–5% of non-small-cell lung cancers. Dysregulation of the MET receptor leads to cell proliferation and survival by activation of the PI3K–AKT–TOR and RAS–RAF–MET–ERK canonical pathways. Targeting the MET tyrosine kinase domain in the setting of MET exon 14 mutations using effective MET tyrosine kinase inhibitors is a current targeted therapy option for patients with metastatic lung cancer. In this Review, we focus on the management of patients with MET exon 14 skipping alterations by addressing the biology of the MET receptor and exon 14 skipping mutations, current treatment strategies, and sequential treatment options based on resistance mechanisms to MET inhibitors in patients with non-small-cell lung cancer.

This article is part of the Treatment of advanced non-small-cell lung cancer: one size does not fit all Special Issue: https://dic-wp.zaphod.dev/special_issues/treatment-of-advanced-non-small-cell-lung-cancer-one-size-does-not-fit-all/

Article Details

Article Type

Review

DOI

10.7573/dic.2022-2-2

Publication Dates

Accepted: ; Published: .

Citation

Blaquier JB, Recondo G. Non-small-cell lung cancer: how to manage MET exon 14 skipping mutant disease. Drugs Context. 2022;11:2022-2-2. https://doi.org/10.7573/dic.2022-2-2

Article Views

Monthly article views (last 12 months)

Drugs in Context PubMed Central
Source HTML views PDF downloads Totals
Drugs in Context since September 15, 2025 235 4 239
PubMed Central since November 1, 2024 2003 146 2149
Totals 2238 150 2384
Register for alerts

I would like to be contacted by Drugs in Context when new articles are posted.

Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.