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Category: Primary Care

Drugs in Context Primary Care welcomes a broad range of article types including original research, study protocols and review articles.

In line with the principle of providing context for healthcare professionals (HCPs) to properly inform and improve disease management in real world medicine, we especially encourage the submission of articles that provide context for trials of drug interventions in order to motivate improvements in disease management by HCPs practising medicine in the front line.

A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond

Lalita Prasad-Reddy, Diana Isaacs

Article Type

Review

Published

08 Jul 2015

Many of the agents used to treat type 2 diabetes have undesirable adverse effects of hypoglycemia and weight gain. Glucagon-like peptide-1 (GLP-1) receptor agonists represent a unique approach to the treatment of diabetes. In this article the authors discuss the various GLP-1 receptor agonists available on the market, specifically focusing on their relative efficacy, safety, and clinical differences as well as their potential benefits in addition to glucose lowering in type 2 diabetes, and describe the adverse effects and toxicities seen with these agents.

Review of the experiences from the first childhood influenza vaccination programme with a live attenuated influenza vaccine in England and Scotland

George Kassianos, Sharon White, Arlene J Reynolds, Sankarasubramanian Rajaram

Article Type

Case Report

Published

01 May 2015

In 2012, the Joint Committee on Vaccination and Immunisation recommended that the UK National Immunisation Programme for influenza be extended to include healthy children/adolescents aged 2–17 years. The extension of this new immunisation programme began in 2013–2014 and targeted children aged 2–3 years in primary care. This article describes the processes utilised in England and Scotland for programme setup, workforce management, identification and care of contraindicated patients, collection of data on vaccine uptake, communication strategies, and education of parents and children. In light of the lessons learnt from these pilot programmes, the authors make recommendations and offer practical advice to help ensure effective preparation and management of new childhood influenza vaccination programmes in other countries.

Clinical factors, including All Patient Refined Diagnosis Related Group severity, as predictors of early rehospitalization after COPD exacerbation

Melissa H Roberts, Douglas W Mapel, Ann Von Worley, Janice Beene

Article Type

Original Research

Published

18 Mar 2015

Patients hospitalized for chronic obstructive pulmonary disease (COPD) exacerbations carry a high risk for early rehospitalization. This study demonstrates that hospitals can use commonly collected clinical information to help identify COPD patients at a high risk of failure after discharge.

Reduction in inpatient resource utilization and costs associated with long-acting injectable antipsychotics across different age groups of Medicaid-insured schizophrenia patients

Siddhesh A Kamat, Steve Offord, John Docherty, Jay Lin, Anna Eramo, Ross A Baker, Benjamin Gutierrez, Craig Karson

Article Type

Original Research

Published

17 Mar 2015

The results from this large cohort study provided naturalistic real-world evidence of the utility of LAIs in patients with schizophrenia and suggest that these agents may help to reduce the risk of relapse across all age groups, especially among younger patients.

Glioblastoma treatment patterns, survival, and healthcare resource use in real-world clinical practice in the USA

Allicia C Girvan, Gebra C Carter, Li Li, Anna Kaltenboeck, Jasmina Ivanova, Maria Koh, Jessi Stevens, Eleanor Hayes-Larson, Michael M Lahn

Article Type

Original Research

Published

10 Mar 2015

Glioblastoma (GB) treatment remains challenging because of recurrence and poorly defined treatment options after first-line therapy. To better understand real-world application of treatment paradigms and their impact on outcomes, the authors describe patterns of GB treatment, outcomes, and use of cancer-related healthcare resource in the USA.