Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Allan R Brasier MD, Istvan Boldogh DM&B, PhD

Article Type

Review

Published

This article reviews recent systems-level studies that provide fundamental new insights into how repetitive activation of innate signaling pathways produce epigenetic ‘training’ to induce adaptive epithelial responses and presents studies demonstrating efficacy of these in reducing airway inflammation in preclinical models

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Targeting eosinophils: severe asthma and beyond

Marco Caminati MD, Francesco Menzella MD, Lucia Guidolin MD, Gianenrico Senna MD

Article Type

Review

Published

This review summarizes the rationale for the use of biologics in eosinophilic diseases and their mechanisms of action.

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