Combination therapy in the treatment of hypertension

Carolina Guerrero-García MD, Alberto Francisco Rubio-Guerra PhD

Abstract

Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart disease. Although modern and effective antihypertensive drugs are available, most patients remain with a suboptimal blood pressure control. Most hypertensive patients will need a combination of antihypertensive agents to achieve the therapeutic goals – recent guidelines recommend initiating treatment with two drugs in those patients with a systolic blood pressure >20 mmHg and/or a diastolic blood pressure >10 mmHg above the goals, and in those patients with high cardiovascular risk. In addition, approximately 25% of patients will require three antihypertensive agents to achieve the therapeutic targets. In this review, we analyse the latest information available regarding the treatment of hypertension with combination therapy.

Article Details

Article Type

Review

DOI

10.7573/dic.212531

Publication Dates

Accepted: ; Published: .

Citation

Guerrero-García C, Rubio-Guerra AF. Combination therapy in the treatment of hypertension. Drugs in Context 2018; 7: 212531. DOI: 10.7573/dic.212531

Article Views

Monthly article views (last 9 months)

Drugs in Context PubMed Central
Source HTML views PDF downloads Totals
Drugs in Context since September 15, 2025 227 4 231
PubMed Central since February 1, 2025 0 0 0
Totals 227 4 227
Register for alerts

I would like to be contacted by Drugs in Context when new articles are posted.

Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.