Combination therapy in the treatment of hypertension

Carolina Guerrero-García MD, Alberto Francisco Rubio-Guerra PhD

Abstract

Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart disease. Although modern and effective antihypertensive drugs are available, most patients remain with a suboptimal blood pressure control. Most hypertensive patients will need a combination of antihypertensive agents to achieve the therapeutic goals – recent guidelines recommend initiating treatment with two drugs in those patients with a systolic blood pressure >20 mmHg and/or a diastolic blood pressure >10 mmHg above the goals, and in those patients with high cardiovascular risk. In addition, approximately 25% of patients will require three antihypertensive agents to achieve the therapeutic targets. In this review, we analyse the latest information available regarding the treatment of hypertension with combination therapy.

Article Details

Article Type

Review

DOI

10.7573/dic.212531

Publication Dates

Accepted: ; Published: .

Citation

Guerrero-García C, Rubio-Guerra AF. Combination therapy in the treatment of hypertension. Drugs in Context 2018; 7: 212531. DOI: 10.7573/dic.212531

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