Articles

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling

Allan R Brasier MD, Istvan Boldogh DM&B, PhD

Article Type

Review

Published

This article reviews recent systems-level studies that provide fundamental new insights into how repetitive activation of innate signaling pathways produce epigenetic ‘training’ to induce adaptive epithelial responses and presents studies demonstrating efficacy of these in reducing airway inflammation in preclinical models

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Neonatal pharmacology and clinical implications

Antonio Ruggiero MD, Anna Ariano MD, Silvia Triarico MD, Michele Antonio Capozza MD, Pietro Ferrara MD, Giorgio Attinà MD

Article Type

Review

Published

This review article analyses the main pharmacokinetic aspects (ADME) that exist during the neonatal period and offers a description of the physiological background for variability in pharmacological dosing.

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Venetoclax: evidence to date and clinical potential

Luis Miguel Juárez-Salcedo MD, Viraj Desai BA, Samir Dalia MD

Article Type

Review

Published

Thsi review article describes the mechanism of action that stands behind the efficacy of venetoclax and provides a summary of available results from clinical trials.

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