eosinophils Archives - Drugs in Context

Effectiveness and safety of mepolizumab in severe refractory eosinophilic asthma: results in clinical practice

Olalla Montero-Pérez PharmD, María Beatriz Contreras-Rey PharmD, Ernesto Sánchez-Gómez PhD

Article Type

Original Research

Published

27 May 2019

This article analyses the effectiveness, clinical outcomes, and safety of mepolizumab in clinical practice.

Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors?

Francesco Menzella MD, Mirella Biava Msc, Diego Bagnasco MD, PhD, Carla Galeone Msc, Anna Simonazzi MD, Patrizia Ruggiero Msc, Nicola Facciolongo MD

Article Type

Review

Published

15 Apr 2019

This article is an indirect comparison among literature data, especially between OCS reduction studies (ZONDA-SIRIUS) and pivotal studies (SIROCCO-MENSA), evaluating whether the clinical efficacy and the steroid-sparing effect of benralizumab may represent an advantage over other compounds. This data could help the clinician in the decision process of treatment choice, within the different available therapeutic options for eosinophilic refractory severe asthma.

Severe refractory asthma: current treatment options and ongoing research

Francesco Menzella MD, Francesca Bertolini MSc, PhD, Mirella Biava MSc, Carla Galeone MSc, Chiara Scelfo MD, Marco Caminati MD

Article Type

Review

Published

05 Dec 2018

In this review, the different biological options available for the treatment of severe refractory asthma, their mechanism of action, and the overlapping aspects of their usage in clinical practice are discussed.