From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease

Kanae Jennifer Nagao MBBS (Hons), FRACP, Neepa J Patel MD

Abstract

Motor complications are responsible for the large burden of disability and poor quality of life in Parkinson’s disease (PD). The pulsatile nature of stimulation with oral dopaminergic therapies due to relatively short pharmacokinetic profiles and dysfunctional gastrointestinal absorption have been attributed to the development of PD motor complications. In this review, we will provide an overview of the pharmacologic and surgical therapies currently available and under investigation for the treatment of motor fluctuations and dyskinesia.

Article Details

Article Type

Review

DOI

10.7573/dic.212592

Categories

Publication Dates

Accepted: ; Published: .

Citation

Nagao KJ, Patel NJ. From medications to surgery: advances in the treatment of motor complications in Parkinson’s disease. Drugs in Context 2019; 8: 212592. DOI: 10.7573/dic.212592

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