Breast cancer, one of the most common malignancies worldwide, is an example of complex disease. Clinical complexity is an increasingly recognized feature of internal medicine and oncology patients, who are often characterized by multifaceted needs determined by both biological (i.e. intrinsic to patient or disease biology) and non-biological (i.e. socioeconomic, cultural, environmental and behavioural) factors. In this series, we try to provide a comprehensive view of breast cancer complexity from a clinical and molecular perspective, with the aim of improving our understanding of the disease and patient care.

Tackling the clinical complexity of breast cancer

Marco Vincenzo Lenti, Federico Sottotetti, Gino Roberto Corazza

Article Type



The authors provide their view about the possible factors triggering clinical complexity, the key issues of clinical complexity and the related unmet needs in breast cancer.

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