chemotherapy Archives - Drugs in Context

TAS-102 in metastatic colorectal cancer (mCRC): efficacy, tolerability, and quality of life in heavily pretreated elderly patients: a real-life study

Giuseppe Cicero MD PhD, Raffaele Addeo MD, Rossella De Luca PhD, Giuseppe Lo Re MD PhD, Leonardo Gulotta MD, Pierenrico Marchesa MD, Gaspare Gulotta MD PhD

Article Type

Original Research

Published

18 Sep 2020

This study evaluates the safety and
efficacy of TAS-102 in heavily pretreated elderly patients with
metastatic colorectal cancer.

Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents

Gabriela Antelo MD, Cinta Hierro MD, MSc, Juan Pablo Fernández MD, Eduardo Baena MD, Cristina Bugés MD, Laura Layos MD, José Luis Manzano MD, Mónica Caro MD, Ricard Mesia MD, PhD

Article Type

Review

Published

15 May 2020

This article discusses the current management of this rare entity and provide an overview of the most relevant molecular findings, whilst illustrating the potential value that prescreening panels can offer, searching for actionable targets (MSI/dMMR, PD-L1, BRAFv600E) to guide therapy with promising agents that could fill a void in this disease.

Anti-angiogenesis therapy, synthetic lethality, and checkpoint inhibition in ovarian cancer: state of the science and novel combinations

Marisa C Liu MD, MPH, Krishnansu S Tewari MD

Article Type

Review

Published

27 Dec 2018

This review summarizes studies related to anti-angiogenic treatment, synthetic lethality, and checkpoint inhibition of ovarian cancer and additionally novel combinations that offer a veritable therapeutic matrix for clinicians to choose from.

Cutaneous side effects of molecularly targeted therapies for the treatment of solid tumors

Daniel I G Cubero MD, PhD, Beatrice Martinez Zugaib Abdalla MD, Jean Schoueri, Fabio Iazetti Lopes, Karine Corcione Turke, Jose Guzman MD, Auro Del Giglio MD, PhD, Carlos D’Apparecida Santos Machado Filho MD, PhD, Vanessa Salzano MD, Dolores Gonzalez Fabra MD

Article Type

Review

Published

17 Jul 2018

This article reviews the cutaneous side effects of main molecularly targeted cancer therapies for solid tumors.